As Gilead's remdesivir remains the only fully approved drug to treat COVID-19, researchers are testing many others, both new and repurposed, against the virus.
Here are nine updates on some of the drugs being tested, reported since the beginning of June:
- GlaxoSmithKline and Vir Biotechnology's COVID-19 antibody drug,sotrovimab,resulted in a 79 percent reductionin the risk of hospitalization from COVID-19 for more than 24 hours in a clinical trial. The National Institutes of Health has authorized sotrovimab for nonhospitalized people with mild-to-moderate COVID-19 who are at high risk of clinical progression.
- Gilead's瑞德西韦, sold under the brand nameVeklury,reduced mortality ratesin hospitalized COVID-19 patients and increased their likelihood of being discharged by day 28 after a five-day regimen. Remdesivir became the first FDA-approved COVID-19 treatment in October.
- The U.S. said itplans to invest more than $3 billionto developantiviral drugsto treat COVID-19. The money will go to speeding up clinical trials of several promising drug candidates.
- Regeneron's COVID-19 antibody cocktail,casirivimab and imdevimab,reduced the risk of death among hospitalized patientsby 20 percent in a phase 3 trial.
- AstraZeneca's COVID-19 antibody drug,AZD7442,does not preventsymptomatic COVID-19 infection in people recently exposed to the virus, a phase 3 trial found.
- Aspirindoes not improve survival ratesfor hospitalized COVID-19 patients, a study conducted by researchers at the University of Oxford in England found
- The U.S.signed a deal to purchase1.7 million courses of Mercks' COVID-19 antiviral drugmolnupiravirfor $1.2 billion if it's authorized by the FDA. It is an experimental oral antiviral designed to treat patients with mild to moderate disease who are at risk of developing severe disease.
- The FDAauthorized an injectable versionof Regeneron's COVID-19 drugREGEN-COV, a combination of two monoclonal antibodies, casirivimab and imdevimab. It was granted emergency use authorization in November for treatment of COVID-19 patients who are at high risk of their cases becoming severe.
- Researchers from the National Institutes of Health foundTempol, an experimental oral drug,may be a promising treatmentfor COVID-19. The study showed the drug can reduce COVID-19 infections by targeting an enzyme the virus needs to make copies of itself in the body.